Current research

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Current research 2017-09-09T06:02:11+00:00

Current research

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Physiotherapy interventions

Prospective Trial for the Evaluation of Safety, Tolerability and Efficacy of the Medical Device Simeox ® Compared to Traditional Respiratory Physiotherapy Techniques for Airway Secretion Clearance.

Aim: to determine the safety of Simeox in the treatment of respiratory disease when compared to traditional physiotherapy for secretion clearance.

 

Multicenter Randomized Placebo-controlled trial to Evaluate the Efficacy of the ELTGOL Technique in the Drainage of Secretions in Patients With Bronchiectasis.

Aim: 1) to evaluate the efficacy of Low expiration open glottis inferolateral (ELTGOL) in stable patients with bronchiectasis compared to placebo; 2) to determine the knowledge of airway clearance techniques and adherence and 3) to assess side effects during ELTGOL on oxygen desaturation, dyspnoea and haemoptysis.

 

Prevalence and impact of Depression and Anxiety symptoms in patients with bronchiectasis

Aim: 1) To evaluate the impact of depression and anxiety symptoms on non-CF bronchiectasis health outcomes (exacerbations, hospitalisation, HRQOL) over 1 year; 2) to estimate the prevalence of anxiety and depression in patients with non-CF bronchiectasis over 6 months; 3) to identify the risk factors associated with depression and anxiety.

 

Bacteriology and Sputum and Systemic Inflammation in Steady-state, Acute Exacerbation and Recovery of Bronchiectasis.

Aim: 1) To study the natural history of bronchiectasis to identify inherited and immune factors that may explain why certain individuals have chronic recurring infections.

 

A Randomised Double Blind 13 Week Crossover Trial of Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Patients With Bronchiectasis.

Aim: 1) determine the effects of hypertonic saline versus normal saline in individuals with mild to severe stable bronchiectasis over 13 weeks on sputum volume, lung function, sputum viscosity/rheology, adherence, cough-related quality of life, HRQOL, signs and symptoms of an exacerbation.

 

Effects of Pulmonary Rehabilitation Associated With Respiratory Therapy vs Respiratory Therapy alone in Physical Capacity, Peripheral Muscle Strength and Quality of Life in Patients With Bronchiectasis: a Randomized Controlled Trial.

Aim: 1) to determine the effects of respiratory therapy with rehabilitation on physical function, inflammatory mediators, peripheral muscle strength, exercise capacity, and quality of life compared to those only performing chest physiotherapy (L’Expiration Lente Totale Glotte Ouverte en decubitus Latéral (Eltgol), autogenous drainage (AD) and shaker).

 

Impact of Pulmonary Resection on Exercise Capacity in Patients With Bronchiectasis.

Aims: 1) to evaluate the impact of lung resection on exercise capacity in patients with bronchiectasis; 2) to evaluate the impact of lung resection on HRQOL and lung function and the presence of predictors of postoperative functional deterioration and the occurrence of complications.

 

A Randomized Controlled Trial of Pulmonary Rehabilitation After Exacerbations of Bronchiectasis

Aims: 1) To determine the effects of pulmonary rehabilitation compared to standard care on exercise capacity in those with exacerbation of bronchiectasis.

 

Bacterial Load Guided Therapy for Severe Exacerbations of Bronchiectasis Requiring IntraVenous Antibiotic Therapy- BLT Br IV Study

Aim: 1) To determine if a shorter duration of antibiotics (8-11 days) for an acute exacerbation of bronchiectasis (when sputum load is low) is effective.

 

A Pilot Study of Pulmonary Rehabilitation Program (PRP) Versus PRP Plus Nutritional Supplementation in Patients With Bronchiectasis: a Randomized Controlled Trial

Aims: to determine the effects of pulmonary rehabilitation twice weekly in hospital and one unsupervised session at home versus pulmonary rehabilitation with nutritional supplement on exercise capacity, body composition, peripheral muscle strength, lung function, respiratory symptoms, physical activity, HRQOL, anxiety and depression, inflammatory markers and oxidation.

 

Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis: a Randomized, Double-blind, Crossover Trial

Aim: to determine the effects of hypertonic saline compared to hyaluronic acid and hypertonic saline and isotonic saline on sputum clearance, cough severity and the safety of these nebulised solutions.

 

Medical trials

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Time to First Pulmonary Exacerbation, Safety and Efficacy of Dual Release Ciprofloxacin for Inhalation-DRCFI Compared With Placebo in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Patients With Non-Cystic Fibrosis Bronchiectasis.

 

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections With Pseudomonas Aeruginosa in Patients With Non-Cystic Fibrosis Bronchiectasis, Including 28 Day Open-Label Extension.

 

A Phase 1 Randomized Double-Blind Placebo-Crossover Safety Trial of DAS181 (Fludase®) in Adult Subjects With Well-Controlled Asthma or Bronchiectasis.

 

A Phase II, Open-label, Multicenter Study to Assess the Tolerance, Safety, Efficacy and Pharmacokinetics/Pharmacodynamics (PK/PD) of POL7080 in the Treatment of Patients With Acute Exacerbation of Non-cystic Fibrosis Bronchiectasis Due to Pseudomonas Aeruginosa Infection Requiring Intravenous Treatment.